Potentiation of immunogenic response
AssigneeConnaught Laboratories Limited
InventorsRobert S. Becker, Karen Biscardi, Laura Ferguson, Lorne Erdile
Life of this patent
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Abstract
An enhanced immune response to antigens, particularly normally weakly-immunogenic viral antigens, such as the HA antigen from influenza virus, is achieved by coadministering the antigen in two different physiochemical forms, particularly to enable presentation of antigen both by B cells and accessory cells.
Claims18
A method for achieving an enhanced immune response to an antigen in a naive animal, wherein a naive animal is an animal which has not been previously immunized by a highly immunogenic form of the antigen, which method comprises the steps of:
- simultaneously administering said antigen to said animal in at least two different physio-chemical forms to provide a synergistic immune response to the antigen in the naive animal greater than the immune response to the individual physiochemical forms of the antigen in the naive animal.
A vaccine for eliciting an immune response to an antigen in a naive animal, wherein a naive animal is an animal which has not been previously immunized by a highly-immunogenic form of the antigen, including humans, which vaccine comprises:
- a first physio-chemical form of said antigen favoring presentation of the antigen by B cells to T cells in the animal,
- a second physio-chemical form of said antigen favoring presentation of the antigen by accessory cells to T cells in the animal, and
- a physiologically-acceptable carrier for said first and second physiochemical forms of the antigen, whereby a synergistic enhanced immune response to said antigen is achieved upon administration of said vaccine to said naive animal in comparison to either of the physio-chemical forms administered alone.
Dependencies are inferred from the claim text.