Targeting of peg antibody conjugates to islet cells
AssigneeUniversity of Utah Research Foundation
InventorsHarvey Jacobs, Sung Wan Kim, Virginie Menard
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Abstract
A method for delaying onset of insulin dependent diabetes mellitus (IDDM) in an individual predisposed to developing the disease is disclosed. The method comprises administering a composition comprising an immunologically effective monoclonal antibody or fragment thereof against glutamic acid decarboxylase (GAD) coupled to a nonimmunogenic hydrophilic polymer that provides a hydration shell around the monoclonal antibody for inhibiting immune recognition thereof. Poly(ethylene glycol) is a preferred polymer. A method of reducing insulitis in an IDDM patient and a composition therefor are also described.
Claims12
A method for delaying onset of insulin dependent diabetes mellitus in an individual predisposed to developing the disease comprising administering to said individual an effective amount of a composition comprising (a) a monoclonal antibody or fragment thereof, wherein said monoclonal antibody or fragment thereof binds glutamic acid decarboxylase and (b) a nonimmunogenic hydrophilic polymer covalently coupled to said monoclonal antibody or fragment thereof, wherein said polymer provides a hydration shell around said monoclonal antibody or fragment thereof.
Dependencies are inferred from the claim text.