Antibody to interleukin-12 receptor
AssigneeHoffmann-La Roche Inc.
InventorsMaurice Kent Gately, David Howard Presky, Chang-you Wu
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Abstract
The present invention relates to a novel antibody against the IL-12 receptor and a novel combination of anibodies anainst the IL-12 receptor. The novel anti-IL-12 receptor anbody, designated as 2B10, provided in accordance with the present invention binds to the human IL-12 receptor but which is not capable of inhibiting the binding of human IL-12 to the high affinity human IL-12 receptor and is not capable of neutralizing human IL-12 bioactivity by binding to human IL-12 receptor.
Claims1
A combination of human IL-12 receptor specific immunoglobulins which is capable of inhibiting the binding of human IL-12 to the high affinity human IL-12 receptor and is capable of neutralizing human IL-12 bioactivity by binding to the human IL-12 receptor, wherein each individual immunoglobulin is not individually capable of inhibiting the binding of human IL-12 to the high affinity human IL-12 receptor.
Dependencies are inferred from the claim text.