Genetically engineered chimeric viruses for the treatment of diseases associated with viral transactivators
AssigneeYale University
InventorsPeter J. Tattersall, Susan F. Cotmore
Life of this patent
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Abstract
The present invention relates to chimeric viruses, the replication of which is regulated by a transactivation signal produced by diseased host cells. The chimeric viruses of the invention can infect both normal and diseased host cells. However, the chimeric virus replicates efficiently in and kills diseased host cells that produce the transactivation signal. The use of such chimeric viruses to treat infectious diseases and cancers are described. A particularly useful embodiment involves the modification of a murine parvovirus that infects human T cells to generate a chimeric parvovirus that is cytocidal to human T cells that express HIV-tat. The chimeric parvovirus can be used to treat HIV-infection.
Claims12
A replication competent chimeric cytocidal parvovirus that infects human host cells, comprising a chimeric regulatory region that initiates and completes the replicative process without the addition of parvoviral genes in trans, of the chimeric cytocidal parvovirus in response to a regulatory factor produced by virus infected human host cells.
A replication competent chimeric cytocidal parvovirus that infects HIV infected human host cells comprising a chimeric regulatory region that initiates and completes replication of the chimeric cytocidal parvovirus without the provision of additional parvovival genes in trans, in response to a HIV-tat produced by HIV-infected host cells.
Dependencies are inferred from the claim text.