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AssigneeBrookhaven Science Associates, LLC
InventorsSuresh C. Srivastava, George E. Meinken, Leonard F. Mausner, Harold L. Atkins
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The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.
A method for palliation of pain associated with cancer in skeletal bone of a human, comprising a step of administering to the human a composition comprising a pharmaceutically acceptable carrier and an Sn-117 m (Sn.sup.4+) chelate complex, wherein the composition has a specific activity of Sn-117m of at least about 2 mCi/mg, at a dosage of between about 10 mCi and about 50 mCi per 70 kg of body weight, wherein the administration of the composition does not result in bone marrow toxicity, thereby relieving said pain.
A method for combined palliation of bone pain and treatment of cancer in skeletal bone of a human, comprising a step of administrating to the human a composition comprising a pharmaceutically acceptable carrier and a Sn-117m (Sn.sup.4+) chelate complex, wherein the composition has a specific activity of Sn-117m of at least about 2 mCi/mg, at a dosage of between about 10 mCi and about 50 mCi per 70 kg of body weight, wherein the administration of the composition does not result in bone marrow toxicity, thereby relieving said pain and effecting regression of said cancer.
A method for combined palliation of pain associated with cancer in skeletal bone of a human and imaging of said bone, comprising steps of:
Dependencies are inferred from the claim text.