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US 5,853,383 AGranted
Preparation for formulations for electrotransport drug delivery
AssigneeAlza Corporation
InventorThomas Owen Murdock
Life of this patent
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Abstract
A method is provided for preparing drug formulations suitable for electrotransport drug delivery. The drug to be delivered, present in salt form, is contacted with an ion exchange material prior to incorporation into the reservoir (26) of an electrotransport delivery system (10). In this way, the drug salt is partially or completely neutralized. This technique is useful for adjusting the pH of the drug formulation without incorporating extraneous materials, e.g., competing ions or the like, into the reservoir (26).
Claims10
A process for making a pH adjusted composition in an electrotransport delivery system comprising the steps of:
- providing an aqueous drug solution including drug ions and counter ions;
- adjusting the pH of the drug solution by contacting an ion exchanger and the drug in solution;
- exchanging hydronium or hydroxyl ions for the counter ions;
- removing the ion exchanger from the aqueous solution;
- and,
- adding the aqueous solution to at least one reservoir of the electrotransport delivery system.
3 more elements
Dependencies are inferred from the claim text.