Process for the production of azomethines and alpha-haloacetanilides
AssigneeZeneca Limited
InventorsKambiz Javdani, Louie A. Nady, Ping H. Sih, Gilbert Rodriguez
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Abstract
Aromatic azomethines are produced by continuous reaction of an aniline with a formaldehyde source, with continuous evaporation to remove residual water of reaction. The azomethine product may be further reacted, either continuously or in batch process, with a haloacetylating agent, and, additionally, with an aliphatic alcohol.
Claims10
In a process for the production of an aromatic azomethine by reaction of an aniline with formaldehyde in which the formaldehyde is provided in the form of a product produced by contacting paraformaldehyde with from about 0.25 to about 3 mole equivalents of an aliphatic alcohol having from one to four carbon atoms in the presence of a catalytic amount of a base, the steps comprising (a) conducting the reaction continuously and (b) continuously evaporating water of reaction from the reaction mixture, wherein steps (a) and (b) are conducted by passing the reaction mixture through one or more evaporators.
Dependencies are inferred from the claim text.