Back to results
US 5,852,199 AGranted
Method for making carbamazephine derivative
AssigneeDade Behring Inc.
InventorChengrong Wang
Life of this patent
Estimating the term…
Abstract
The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C.dbd.O, CH.sub.2 or SO.sub.2 ; Y is C.dbd.O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.
Claims6
A method comprising the steps of:
- reacting triphosgene with iminostilbene in a substantially oxygen free environment;
- adding hydrazine monohydrate and refluxing in a substantially free environment for a period of time sufficient to permit the formation of a precipitate having the structural formula:
- ##STR12## filtering the precipitate;
- and, reacting the precipitate in the presence of a base with a reactant selected from the group consisting of succinic anhydride, bromoacetic acid and halogen substituted aliphatic sulfonic acid at a temperature and for a period of time sufficient to permit the formation of a carbamazepine-acid having the structural formula ##STR13## where X is selected from the group consisting of C.dbd.O, CH2 and SO2;
- Y is selected from the group consisting of C.dbd.O, CH2 and SO2;
- and R is an aliphatic alkyl group with straight or branched chains.
3 more elements
Dependencies are inferred from the claim text.