Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them

A cyclic urea derivative of the formula ##STR24## wherein X, represents a carbonyl group;

• Y represents an ethylene group;
• one of the groups R.sub.a or R.sub.b represents a group of thc formula
• A--B----C--
• wherein A represents a straight-chained or branched C.sub.1-5 -aminoalkyl group, an amino, amidino or guanidino group, whilst in each of the above-mentioned groups at one of the nitrogen atoms, one or two hydrogen atoms may be replaced by a C.sub.1-4 -alkyl or one hydrogen atom may be replaced by a C.sub.2-5 -alkoxycarbonyl group or by an alkylcarbonyl, arylcarbonyl, aryloxycarbonyl or aralkoxycarbonyl group, or A may represent a cyano group or a cyanoalkyl group having 1 to 4 carbon atoms in the alkyl moiety;
• B represents a bond, and
• C represents a phenylene group which may be mono- or disubstituted by fluorine, chlorine or bromine atoms, by C.sub.1-4 -alkyl groups, by trifluoromethyl, hydroxy, alkoxy, alkylsulphenyl, alkylsulphinyl, alkylsulphonyl, (R.sub.1).sub.2 N--,(R.sub.1).sub.2 NCO--,(R.sub.1).sub.2 NSO.sub.2 -- or nitro groups or by R.sub.1 NH-groups substituted by an alkylcarbonyl, aralkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, alkylsulphonyl, aralkylsulphonyl or arylsulphonyl group, whilst the substituents may be identical or different;
• the other of the groups R.sub.a or R.sub.b represents a group of the formul a
• F--E--D--
• wherein D represents a cyclohexaline group optionally substituted by an alkyl, aralkyl or aryl group, wherein one CH moiety is replaced by a nitrogen atom, whilst additionally one methylene group adjacent to the nitrogen atom may be replaced by a carbonyl group;
• E represents
• a C.sub.1-5 -alkylene group or a C.sub.2-5 -alkenylene group, each of which may be substituted by one or two alkyl groups, or by a hydroxy, alkoxy, amino, alkylamino, aralkylamino, dialkylamino, bis(aralkyl)amino, carboxyalkyl, alkoxycarbonylalkyl or aralkoxycarbonylalkyl group;
• and
• F represents a carbonyl group substituted by a hydroxy or C.sub.1-6 -alkoxy group, whilst a C.sub.1-3 -alkoxy group may be substituted in the 1-, 2- or 3-position by an aryl group, whilst if A represents a cyano group or an amino or aminoalkyl group optionally benzoylated or benzyloxy-carbonylated at the nitrogen atom, the shortest spacing between the nitrogen atom of these groups and group F is at least 10 bonds;
• or a tautomer or salt thereof,
• and, wherein, unless otherwise specified,
• the above-mentioned alkyl, alkylene, alkenylene or alkoxy moieties may each contain 1 to 3 carbon atoms, and
• the term "an aryl group" used above denotes a phenyl group which may be monosubstituted by a trifluoromethyl, carboxy, (R.sub.3).sub.2 NCO--, alkoxycarbonyl, alkylcarbonyl, alkylsulphenyl, alkylsulphinyl, alkylsulphonyl, nitro, (R.sub.3).sub.2 N--, alkylcarbonyl-NR.sub.3 -, aralkylcarbonyl-NR.sub.3 -, arylcarbonyl-NR.sub.3 -, heteroarylcarbonyl-NR.sub.3 -, alkylsulphonyl-NR.sub.3 -, aralkylsulphonyl-NR.sub.3 -, arylsulphonyl-NR.sub.3 - or (R.sub.3).sub.2 N-sulphonyl group or may be mono-, di- or trisubstituted by fluorine, chlorine or bromine atoms or by hydroxy, alkoxy or alkyl groups having 1 to 4 carbon atoms.