Basic fibroblast growth factor (bFGF) muteins
AssigneeTakeda Chemical Industries, Ltd.
InventorsMasaharu Senoo, Reiko Sasada, Tsutomu Kurokawa, Koichi Igarashi
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Abstract
A mutein of basic fibroblast growth factors (bFGF) possesses fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells and angiogenic activity, has high stability and is low toxicity. And therefore, the present mutein is advantageously used as a healing accelerator for burns etc., a therapeutic drug for thrombosis etc., and a cell cultivation promoter.
Claims13
A mutein of basic fibroblast growth factor (bFGF) wherein at least one constituent cysteine of bFGF is replaced by another amino acid so that the mutein has greater stability under acidic conditions than the bFGF in at least one of the following properties:
- fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells or angiogenic activity.
Dependencies are inferred from the claim text.