Phosgenated oxime resins and their preparation
AssigneeE. I. Du Pont de Nemours and Company
InventorMark Andrew Scialdone
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Abstract
This invention relates to methods for preparing novel, solid-phase transfer reagents, specifically phosgenated oxime resins and non-symmetrical ureas, that are useful as supports in combinatorial synthesis for the creation of libraries of compounds for lead identification.
Claims4
The process for preparing a solid phase reagent useful in chemical synthesis comprising:
- reacting an excess of phosgene with a ketoxime of the formula ##STR33## wherein Z is the recurring part of a carbonaceous polymeric backbone or side chain thereof and EWG is at least one electron-withdrawing group, to produce the corresponding oxime-derived chloroformate.
A composition of matter of the formula ##STR34## wherein Z is the recurring part of a carbonaceous polymeric backbone or side chain thereof and EWG is an electron withdrawing group.
A solid phase reagent is of the formula ##STR35## wherein Z is the recurring part of a carbonaceous polymeric backbone or side chain thereof, EWG is an electron-withdrawing group and R.sub.1 NH--is derived from an initial primary amine addition of an amine of the formula R.sub.2 R.sub.3 NH.
A process for preparing a non-symmetrical urea of the formula ##STR36## wherein R.sub.1 and R.sub.2 are independently selected from a group consisting of optionally substituted alkyl or optionally substituted aryl and R.sub.3 is independently selected from a group consisting of optionally substituted alkyl or optionally substituted aryl or hydrogen, the process comprising
- contacting the solid phase reagent of the formula ##STR37## wherein Z is the recurring part of a carbonaceous polymeric backbone or side chain thereof, EWG is an electron-withdrawing group and R.sub.1 NH--is derived from an initial primary amine addition with an amine of the formula R.sub.2 R.sub.3 NH.
Dependencies are inferred from the claim text.