Phenylacetate and derivatives alone or in combination with other compounds against neoplastic conditions and other disorders
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorDvorit Samid
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Abstract
Methods of inhibiting IL-6 in a cell by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof.
Claims11
A method of inhibiting the production of IL-6 in a cell, comprising contacting the cell with an IL-6 inhibiting amount of a phenylacetic acid derivative of the formula:
- ##STR3## ;
- wherein R.sub.0 =aryl, phenoxy, substituted aryl or substituted phenoxy;
- R.sub.1 and R.sub.2 are, independently, H, lower alkoxy, hydroxy, lower straight and branched chain alkyl or halogen;
- R.sub.3 and R.sub.4 are, independently, H, lower alkoxy, lower straight and branched chain alkyl or halogen;
- and
- n=an integer from 0 to 2;
- salts thereof, stereoisomers thereof;
- and mixtures thereof.
A method of inducing the production of TGF.alpha. in a cell, comprising contacting the cell with a TGF.alpha. inducing amount of a phenylacetic acid derivative of the formula:
- ##STR4## ;
- wherein R.sub.0 =aryl, phenoxy, substituted aryl or substituted phenoxy;
- R.sub.1 and R.sub.2 are, independently, H, lower alkoxy, hydroxy, lower straight and branched chain alkyl or halogen;
- R.sub.3 and R.sub.4 are, independently, H, lower alkoxy, lower straight and branched chain alkyl or halogen;
- and
- n=an integer from 0 to 2;
- salts thereof;
- stereoisomers thereof;
- and mixtures thereof.
A method of inhibiting the production of TGF-.beta.2 in a cell, comprising contacting the cell with an TGF-.beta.2 inhibiting amount of a phenylacetic acid derivative of the formula:
- ##STR5## ;
- wherein R.sub.0 =aryl, phenoxy, substituted aryl or substituted phenoxy;
- R.sub.1 and R.sub.2 are, independently, H, lower alkoxy, hydroxy, lower straight and branched chain alkyl or halogen;
- R.sub.3 and R.sub.4 are, independently, H, lower alkoxy, lower straight and branched chain alkyl or halogen;
- and
- n=an integer from 0 to 2;
- salts thereof, stereoisomers thereof, and mixtures thereof.
Dependencies are inferred from the claim text.