Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof
AssigneeBTG International Limited
InventorRoger Spencer Jones
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Abstract
An improved process for the production of a pharmaceutical composition comprising p-hydroxyacetanilide and L-cysteine or a compound which is converted thereto in vivo comprises mixing p-hydroxyacetanilide and L-cysteine or its precursor in the solid state and then shaping the solid mixture.
Claims9
A solid ungranulated particulate mixture suitable for use in the manufacture of a shaped pharmaceutical product by direct compression without use of a granulation step comprising p-hydroxyacetanilide and L-cysteine or a compound which is converted thereto in vivo wherein the L-cysteine or its precursor is from 10 to 50% by weight of the amount of p-hydroxyacetanilide and is substantially of particle size less than 1,000 microns.
A directly compressed shaped pharmaceutical composition in tablet form comprising a non-granular solid mixture of p-hydroxyacetanilide and L-cysteine or a compound which is converted thereto in vivo together with a physiologically acceptable solid carrier wherein the amount of L-cysteine or its precursor is from 10 to 50% by weight of the amount of p-hydroxyacetanilide.
Dependencies are inferred from the claim text.