Aromatic ethers derived from indoles which are useful as medicaments
AssigneePierre Fabre Medicament
InventorsMichel Perez, Serge Halazy, Gareth John, Jean-Pierre Valentin, Peter Pauwels
Life of this patent
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Abstract
The present invention relates to new aromatic ethers derived from indole and having general formula (I) as well as to their preparation methods, pharmaceutical compositions containing them and their utilization as a medicament for the treatment of diseases linked to the dysfunction of the 5HT.sub.1 -like receptors. ##STR1##
Claims28
A compound corresponding to general formula (I);
- ##STR57## in which R.sub.1 represents an amino residue corresponding to formula (i):
- ##STR58## in which n represents an integer between 1 and 5, R.sub.4 represents a hydrogen, a linear or branched alkyl group comprising from 1 to 6 carbon atoms or a (CH.sub.2).sub.m OR' group in which m represents an integer between 1 and 5, and R' is a linear or branched alkyl group comprising from 1 to 6 carbon atoms,
- R.sub.5 represents a hydrogen, or a linear or branched alkyl group comprising from 1 to 6 carbon atoms,
- R.sub.2 represents hydrogen, or R.sub.1 and R.sub.2, taken together, form a ring with 6 carbon atoms substituted with an amine functional group (NR.sub.4 R.sub.5) where R.sub.4 and R.sub.5 are as defined above,
- R.sub.3 represents hydrogen, an alkyl residue comprising from 1 to 5 carbon atoms or an aromatic group,
- X may be omitted or may represent either a linear or branched alkyl chain comprising from 1 to 8 carbon atoms or an aromatic group or alternatively an arylalkyl group comprising from 1 to 10 carbon atoms which may be substituted at various positions with a linear or branched alkyl group comprising from 1 to 6 carbon atoms, an oxygen atom, an aryl group, a halogen atom, an alcohol group, an ether group, an ester group, a nitrile group, a nitro group, a ketone group, a thiol group, a thioether group, and an amine group, and
- Y represents NHSO.sub.2 R'.sub.6, where R'.sub.6 represents a linear or branched alkyl chain from 1 to 8 carbon atoms, a cycloalkyl from 4 to 10 carbon atoms, an aromatic residue which are variously substituted, and salts, hydrates, solvates, tacemates and bioprecursors thereof.
A process for the preparation of a compound of formula (I), comprising the step of converting a compound of general formula (I) or a salt or a derivative comprising a group for protecting such a compound, to another compound of general formula (I).
Dependencies are inferred from the claim text.