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US 5,852,047 AGranted
Pharmaceutical product comprising a salicylate of an esterifiable ace-inhibitor
AssigneeCal International Limited
InventorsWilliam Byrne, Andrew Rynne
Life of this patent
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Abstract
Salicylates of esterifiable ACE-inhibitors, especially captopril-S-aspirinate, and processes for their preparation are described. Such compounds are useful as analgesics, in the process of anti-clotting and as anti-hypertensive pharmaceutical reagents.
Claims13
Captopril-S-aspirinate.
A process for preparing Captopril-S-aspirinate comprising the steps of:
- protecting the phenolhydroxy group in salicylic acid;
- activated coupling of the captoprilthiol grouping with the activated salicylic acid;
- removing protecting groups;
- and
- acetylation of the deprotected phenolic hydroxy to yield the desired captopril aspirinate.
2 more elements
A pharmaceutical product comprising a salicylate of an esterifiable ACE-inhibitor, wherein said ACE-inhibitor is captopril.
A pharmaceutical composition comprising captopril-S-aspirinate.
Dependencies are inferred from the claim text.