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US 5,852,039 AGranted
Pharmaceutical composition containing quinoline or quinazoline derivatives
AssigneeTakeda Chemical Industries, Ltd.
InventorsTakashi Sohda, Shigehisa Taketomi, Atsuo Baba
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Abstract
The present invention provides a pharmaceutical composition for inhibiting bone resorption or for preventing or treating osteoporosis which comprises a quinoline or quinazoine derivative as an active ingredient.
Claims35
A compound of the formula (I'):
- ##STR331## wherein Y is C-G in which G is an amidated carboxyl group, or hydroxymethyl group;
- R is an optionally substituted hydrocarbon group or optionally substituted heterocyclic group;
- X is an oxygen atom or optionally oxidized sulfur atom;
- n is 1;
- k is 0 or 1;
- each of the rings A and B may optionally be substituted;
- and ##STR332## or a pharmaceutically acceptable salt thereof.
4 more elements
A compound of the formula (I'):
- ##STR333## wherein Y is C-G in which G is an amidated carboxyl group, or hydroxymethyl group;
- R is represented by a group of the formula:
- --CH.sub.2 --X.sup.1 --Z.sup.1
- wherein X.sup.1 is an oxygen atom, optionally oxidized sulfur atom or --(CH.sub.2).sub.m -- in which m is an integer of 1 to 5, and Z.sup.1 is an optionally substituted hydrocarbon group, optionally substituted heterocyclic group or optionally substituted amino group;
- provided that X.sup.1 is not --(CH.sub.2).sub.m -- when Z.sup.1 is all optionally substituted hydrocarbon group;
- X is an oxygen atom or optionally oxidized sulfur atom;
- n is 0;
- k is 0 or 1;
- each of the rings A and B may optionally be substituted;
- G and R may be linked together to form a 5-membered ring, wherein the resulting compound is represented by the formula (II) or (III):
- ##STR334## wherein R.sup.3 is an optionally substituted hydrocarbon group or optionally substituted heterocyclic group;
- Z.sup.1 is an optionally substituted hydrocarbon group, optionally substituted heterocyclic group or optionally substituted amino group;
- k, ring A and ring B are as defined above:
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.