Method for treating anxiety

A method for treating anxiety in a human comprising administering to the human an antianxiety dose of a compound of formula I ##STR18## wherein W is oxygen or sulfur;

• R is hydrogen, amino, halogen, NHR.sup.6, NR.sup.6 R.sup.7, R.sup.4, --OR.sup.4, --SR.sup.4, --SOR.sup.4, --SO.sub.2 R.sup.4, C.sub.3-10 -cycloalkyl, C.sub.4-12 -(cycloalkyalkyl), --Z--C.sub.3-10 -cycloalkyl, --Z--C.sub.4-12 -(cycloalkylalkyl) , --OR.sup.5 Y, --SR.sup.5 Y, --OR.sup.5 ZY, --SR.sup.5 ZY, --OR.sup.5 ZR.sup.4, --S--R.sup.5 --Z--R.sup.4, or phenyl or benzyloxycarbonyl, each of which is optionally substituted with one or more substituents independently selected from halogen, --CN, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, --OCF.sub.3, --CF.sub.3, --CONH.sub.2 or --CSNH.sub.2 ;
• R.sup.4 is C.sub.1-15 -alkyl, C.sub.2-15 -alkenyl, or C.sub.2-15 -alkynyl, each of which is optionally substituted with one or more substituents independently selected from halogen, --CF.sub.3, --CN, Y, phenyl and phenoxy, wherein phenyl or phenoxy is optionally substituted with one or more substituents independently selected from halogen, --CN, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, --OCF.sub.3, --CF.sub.3, --CONH.sub.2 and --CSNH.sub.2 ;
• Z is oxygen or sulphur,
• R.sup.5 is C.sub.1-15 -alkylene, C.sub.2-15 -alkenylene, or C.sub.2-15 -alkynylene;
• Y is a 5 or 6 membered heterocyclic group;
• G is an azacyclic or azabicyclic ring system selected from:
• ##STR19## or G is C.sub.3 -C.sub.8 cycloalkyl optionally substituted with R.sup.1 substituents;
• or C.sub.1-6 -alkyl optionally substituted with --NR.sup.6 R.sup.7 ;
• R.sup.1 and R.sup.2 independently are hydrogen, C.sub.1-15 -alkyl, C.sub.2-5 -alkenyl, C.sub.2-5 -alkynyl, C.sub.1-10 -alkoxy, or C.sub.1-5 -alkyl having one or more --OH, --COR.sup.6', CH.sub.2 OH, halogen, --NH.sub.2, carboxy or phenyl substituents;
• R.sup.3 is hydrogen, C.sub.1-5 -alkyl, C.sub.2-5 -alkenyl or C.sub.2-5 -alkynyl;
• R.sup.6 and R.sup.7 independently are hydrogen or C.sub.1-6 -alkyl;
• or R.sup.6 and R.sup.7 together with the nitrogen atom form a 4- to 6-membered ring;
• R.sup.6' is hydrogen or C.sub.1-6 -alkyl;
• m, n, p, and r, independently, are 0, 1 or 2;
• q is 1 or 2;
• and
• - - - is a single or double bond;
• or
• a pharmaceutically acceptable salt or solvate thereof.