Indole derivatives, process for producing the same and medicinal uses of the same
AssigneeToray Industries, Inc.
InventorsHiroshi Nagase, Akira Mizusuna, Koji Kawai, Izumi Nakatani
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Abstract
A novel compound which is a .delta.-opioid antagonist having high selectivity and activity, that exhibits immunosuppressive action, antiallergic action, anti-inflammatory action and brain cell-protecting action is disclosed. The compound according to the present invention is an indole derivative represented by the formula (I): ##STR1## and pharmaceutically acceptable acid addition salts thereof. The present invention also provides an immunosuppressive agent, antiallergic agent, anti-inflammatory agent and brain cell-protecting agent comprising the derivative or the salt as an effective ingredient.
Claims3
An indole derivative represented by the formula (I):
- ##STR43## wherein R.sup.1 represents cyclopropylmethyl or allyl;
- R.sup.2 represents hydrogen, hydroxy, C.sub.1 -C.sub.5 alkanoyloxy or C.sub.1 -C.sub.5 alkoxy;
- R.sup.3 represents hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkanoyl or benzyl;
- R.sup.4 represents hydrogen, C.sub.1 -C.sub.5 alkyl or benzyl;
- R.sup.5 represents (CH.sub.2).sub.n NR.sup.8 R.sup.9 or CONR.sup.8 R.sup.9 wherein n represents an integer of 1-3, R.sup.8 and R.sup.9 are the same or different and represent C.sub.1 -C.sub.5 alkyl, or C.sub.4 -C.sub.6 cycloalkylalkyl and
- R.sup.6 represents hydrogen
- or pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.