Pyrimidinylpyrazole derivatives
AssigneeDaiichi Pharmaceutical Co., Ltd.
InventorsAkio Ejima, Masamichi Sugimori, Ikuo Mitsui
Life of this patent
Estimating the term…
Abstract
The present invention provides a novel compound which is represented by formula (I): ##STR1## wherein preferable examples of R.sup.1 to R.sup.6 are as follows; R.sup.1 and R.sup.2 are each an alkyl group optionally substituted by a halogen atom, an amino group, a hydroxyl group, an alkoxyl group or a thiol group, a hydrogen atom, a halogen atom or an alkoxyl group; R.sup.3 is a hydrogen atom; R.sup.4 is a methyl group; R.sup.5 is a hydrogen atom or an alkyl group; and R.sup.6 is a group of the formula: ##STR2## wherein Z is a phenyl group; and has an antitumor effect.
Claims11
A compound represented by the following formula (I) or its salt:
- ##STR11## wherein R.sup.1 and R.sup.2 may be either the same or different and each represents an atom or a substituent selected from the group consisting of:
- (1) a hydrogen atom,
- (2) a halogen atom,
- (3) an amino group,
- (4) an alkylamino group,
- (5) a dialkylamino group,
- (6) a hydroxyl group,
- (7) a thiol group,
- (8) an alkylthio group,
- (9) an alkoxyl group,
- (10) a cyano group,
- (11) a carbamoyl group,
- (12) an alkyl group optionally-substituted by a halogen atom, an amino group, an alkylamino group, a dialkylamino group, a hydroxyl group, an alkoxyl group or a thiol group, and
- (13) an alkenyl group optionally substituted by a halogen atom, an amino group, an alkylamino group, a dialkylamino group, a hydroxyl group, an alkoxyl group or a thiol group;
- R.sup.3 represents a hydrogen atom or an alkyl group;
- R.sup.4 represents a hydrogen atom, an alkyl group, a phenyl group or a benzyl group;
- R.sup.5 represents a hydrogen atom or an alkyl group;
- and
- R.sup.6 represents a tetrahydroisoquinolyl group,
- a morpholinyl group,
- a piperidyl group,
- a piperazinyl group, ##STR12## wherein Z represents a phenyl group, a pyridyl group,
- a pyrimidinyl group,
- a pyrazinyl group,
- a pyridazinyl group,
- a piperidyl group,
- a benzyl group,
- a benzhydryl group, ##STR13## and n represents an integer of from 1 to 3;
- and R.sup.6 is optionally substituted by one or more atom(s) and/or substituent(s) selected from a group consisting of:
- a halogen atom,
- an amino group,
- an alkylamino group,
- a dialkylamino group,
- an acetylamino group,
- a nitro group,
- a hydroxyl group,
- a thiol group,
- an alkylthio group,
- an alkoxyl group,
- a cyano group,
- a carbamoyl group,
- an alkyl group optionally substituted by a halogen atom, an amino group, an alkylamino group, a dialkylamino group, a hydroxyl group, an alkoxyl group or a thiol group, and
- an alkenyl group optionally substituted by a halogen atom, an amino group, an alkylamino group, a dialkylamino group, a hydroxyl group, an alkoxyl group or a thiol group.
Dependencies are inferred from the claim text.