Benzimidazole derivatives

A process for preparing a compound represented by the chemical formula (1), which comprises reacting a compound represented by the chemical formula (7) with a carboxylic acid derivative represented by the chemical formula (8):

• ##STR3589## wherein X, Y and Z each independently means CH, N, NH, N(CH.sub.2).sub.t CH.sub.3, S or O with the proviso that X, Y and Z do not all have the same meaning at the same time and t is an integer of 0-5, m and n are integers of 0-5, R.sub.1 and R.sub.2 each independently means a hydrogen atom, a C.sub.1-20 alkyl group, a C.sub.1-10 haloalkyl group, a C.sub.1-10 alkoxyl group, a hydroxyl group, a C.sub.1-10 alkylthio group, a substituted or unsubstituted amino group, a substituted or unsubstituted ammonium group, a substituted or unsubstituted sulfonium group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted 5-membered heteroring, a substituted or unsubstituted 6-membered heteroring, a substituted or unsubstituted fused heteroring, substituted or unsubstituted amidino group, a substituted or unsubstituted guanidino group, an amino acid residual group, or a group represented by the chemical formula (2):
• ##STR3590## wherein R.sub.3 means (CH.sub.2).sub.r or (CH.sub.2).sub.r O in which r stands for an integer of 0-5 and the O atom is located closer to the phenyl group, R.sub.4 means a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.1-10 alkoxyl group, a halogen atom, a trifluoromethyl group, a cyano group, an amidino group, a guanidino group, a carboxyl group or --COR.sub.7 in which R.sub.7 means a C.sub.1-5 alkyl group, an alkylamino group which may be substituted by a substituted or unsubstituted amino group, an amino group which may be substituted by a substituted or unsubstituted phenyl group, or a substituted or unsubstituted benzylamino group, R.sub.5 means a hydrogen atom, a C.sub.1-10 alkyl group, a C.sub.1-10 alkoxyl group, a halogen atom, or --(CH.sub.2).sub.p N(R.sub.8).sub.2 or --(CH.sub.2).sub.p NR.sub.8 R.sub.9 in which p stands for an integer of 0-5, or R.sub.4 and R.sub.5 may form a ring when R.sub.4 and R.sub.5 take mutually adjacent positions, R.sub.6 means a hydrogen atom, --(CH.sub.2).sub.p N(R.sub.8).sub.2 or --(CH.sub.2).sub.p NR.sub.8 R.sub.9 wherein in each case of R.sub.5 and R.sub.6, R.sub.8 means --CH.sub.2 CH.sub.2 W, R.sub.9 means a C.sub.1-5 alkyl group or a mesyl group, W means a halogen atom, a hydroxyl group, a mesyloxy group, a tosyloxy group or --OCOR.sub.7 in which R.sub.7 and p have the same meaning as defined above.