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US 5,852,010 AGranted
Inhibitors of farnesyl-protein transferase
AssigneeMerck & Co., Inc.
InventorsSamuel L. Graham, Neville J. Anthony, John S. Wai
Life of this patent
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Abstract
The present invention is directed to substituted benozdiazepine compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
Claims4
A compound which inhibits farnesyl-protein transferase which is:
- 3(R)-3-1-(4-Cyanobenzyl)imidazol-5-yl-methylamino!-5-phenyl-1-(2,2,2-trifl uoroethyl)-H-benzoe!1,4!diazepine-2-one;
- 3(S)-3-1-(4-Cyanobenzyl)imidazol-5-yl-methylamino!-5-phenyl-1-(2,2,2-trifl uoroethyl)-H-benzoe!1,4!diazepine-2-one;
- 3(R)-3-1-(4-Cyanobenzyl)imidazol-5-yl-acetylamino!-5-phenyl-1-(2,2,2-trifl uoroethyl)-H-benzoe!1,4!diazepine-2-one;
- 3(S)-3-1-(4-Cyanobenzyl)imidazol-5-yl-acetylamino!-5-phenyl-1-(2,2,2-trifl uoroethyl)-H-benzoe!1,4!diazepine-2-one;
- 3(R)-3-1-(4-Cyanobenzyl)imidazol-5-yl-acetylamino!-5-(4-fluorophenyl-1-(2, 2,2 trifluoroethyl)-H-benzoe!1,4!diazepine-2-one;
- 3(R)-3-1-(4-Cyanobenzyl)imidazol-5-yl-ethylamino -5-phenyl-1-(2,2,2-trifluoroethyl)-H-benzoe!1,4!diazepine-2-one;
- and
- 3(S)-3-1-(4-Cyanobenzyl)imidazol-5-yl!-ethylamino -5-phenyl-1-(2,2,2-trifluoroethyl)-H-benzoe!1,4!diazepine-2-one.
5 more elements
Dependencies are inferred from the claim text.