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AssigneeThe Rockefeller University
InventorsAnthony Cerami, Peter C. Ulrich, Michael A. Brownlee
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The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. Suitable agents may contain an active nitrogen-containing group, such as a hydrazine group. Particular agents comprise aminoguanidine, .alpha.-hydrazinohistidine and mixtures thereof. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
A composition for inhibiting the advanced glycosylation of a target protein comprising an agent capable of reacting with a carbonyl moiety of an early glycosylation product formed by the initial glycosylation of the target protein, together with a carrier therefor, wherein said agent consists essentially of a compound selected from the group consisting of aminoguanidine, its pharmaceutically acceptable salts, and mixtures thereof.
A pharmaceutical composition for administration to an animal to inhibit the advanced glycosylation of a target protein within said animal, comprising a pharmaceutically effective amount of an agent capable of reacting with a carbonyl moiety of an early glycosylation product formed by the initial glycosylation of said target protein, and a pharmaceutically acceptable carrier, wherein said agent consists essentially of a compound selected from the group consisting of aminoguanidine, its pharmaceutically acceptable salts, and mixtures thereof.
A method for treating an animal to inhibit the formation of advanced glycosylation end products of a target protein within said animal, said method comprising administering to said animal an effective amount of a pharmaceutical composition, said pharmaceutical composition comprising an agent capable of reacting with a carbonyl moiety of an early glycosylation product formed by the initial glycosylation of said target protein,
A method for treating an animal to inhibit the formation of advanced glycosylation end products of a structural protein within said animal, said method comprising administering to said animal an effective amount of a pharmaceutical composition, said pharmaceutical composition comprising an agent capable of reacting with a carbonyl moiety of an early glycosylation product formed by the initial glycosylation of said structural protein, wherein said agent comprises a compound selected from the group consisting of aminoguanidine, its pharmaceutically acceptable salts, and mixtures thereof.
Dependencies are inferred from the claim text.