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US 5,851,994 AGranted
Compositions that inhibit wound contraction and methods of using same
AssigneeLa Jolla Cancer Research Foundation
InventorsRonda Schreiber, James Polarek
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AssigneeLa Jolla Cancer Research Foundation
InventorsRonda Schreiber, James Polarek
Estimating the term…
The present invention provides methods for reducing or inhibiting wound contraction in a subject having a wound comprising administering to the subject a pharmaceutical composition comprising a peptide or a polypeptide. The invention provides, for example, a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising a peptide having more than three consecutive basic amino acids. The invention also provides a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising a peptide containing the sequence arginine-glycine-aspartic acid and a basic amino acid sequence or a pharmaceutical composition comprising a peptide containing therein a sequence of six consecutive amino acid residues of which at least about four of the six amino acid residues are basic amino acid residues. The invention also provides a method of reducing or inhibiting wound contraction comprising the administration of a pharmaceutical composition comprising decorin.
A method of reducing or inhibiting wound contraction in a subject, comprising administering to said subject a pharmaceutical composition comprising a peptide having more than three consecutive basic amino acid residues and a pharmaceutically acceptable carrier.
A method of reducing or inhibiting wound contraction in a subject, comprising administering to said subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a peptide containing the amino acid sequence arginine-glycine-aspartic acid and a basic amino acid sequence.
A method of reducing or inhibiting wound contraction in a subject, comprising administering to said subject a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a peptide of six to about thirty amino acid residues containing therein a sequence of six consecutive amino acid residues of which at least about four of said six amino acid residues are basic amino acid residues.
Dependencies are inferred from the claim text.