Suppression of tumor cell growth by syndecan-1 ectodomain
AssigneeBiotie Therapies, Inc.
InventorsMarkku Jalkanen, Marku Mali
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Abstract
Methods of reducing tumor growth, including the suppression of tumor growth in a patient, are provided by the administration of efficacious levels of syndecan ectodomain to the extracellular environment of the tumor cell. Pharmaceutically acceptable compositions of syndecan are also provided.
Claims24
A method of decreasing the growth of a tumor cell wherein said method comprises providing efficacious levels of syndecan ectodomain to the extracellular environment of said cell, wherein said syndecan ectodomain causes said cell to develop a more differentiated phenotype than is displayed by said cell in the absence of said efficacious levels of said syndecan ectodomain.
A method for treating a patient in need of treatment to reduce or suppress the growth of a tumor in said patient, wherein said method comprises administering to said patient a composition that comprises efficacious levels of syndecan ectodomain to the extracellular environment of said cell, wherein said syndecan ectodomain causes said cell to develop a more differentiated phenotype than is displayed by said cell in the absence of said efficacious levels of said syndecan ectodomain.
A pharmaceutically acceptable composition for administration to a patient, said composition comprising a protein having a domain consisting of a human syndecan ectodomain.
Dependencies are inferred from the claim text.