Treatment of growth hormone deficiency
AssigneeNovo Nordisk A/S
InventorHans Holmegaaard S.o slashed.rensen
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Abstract
A pharmaceutical formulation comprising a growth hormone and asparagine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature. The formulation may be used to treat a patient with a disorder associated with growth hormone deficiency.
Claims7
A method for treating a disorder associated with growth hormone deficiency comprising administering a pharmaceutical formulation comprising human growth hormone and asparagine, in which asparagine is present in an amount effective to stabilize human growth hormone.
Dependencies are inferred from the claim text.