Treatment of tumors by arginine deprivation
OwnerSlobodan Tepic, Pawel Pykinventors
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Abstract
Method, compositions and apparatus for the treatment of tumors by systemic deprivation of an essential amino acid, preferably of arginine, by extracorporeal treatment of the patient's blood characterized by molecular exchange between the blood and a dialyzing fluid which contains most of the essential low-molecular substances found in blood plasma with the exception of at least one of the essential amino acids. The release of muscular protein amino acids can be limited by use of an insulin/glucose clamp. The treatment process can be used in conjunction with chemotherapy.
Claims13
A method for the treatment of tumors in a patient comprising systemic removal of an essential amino acid from the blood by extracorporeal treatment of the patient's blood comprising the steps of:
- removing blood from the patient;
- treating the blood to remove at least one essential amino acid by molecular exchange between the blood and a dialyzing fluid;
- returning the blood to the patient, wherein concurrent with said treatment of the blood, the patient is administered an effective amount of a composition which limits the release of muscular protein amino acids.
A method for the treatment of tumors in a patient comprising systemic removal of at least one essential amino acid from the blood by extracorporeal treatment of the patient's blood by molecular exchange between the blood and a dialyzing fluid which contains most of the essential low-molecular substances found in blood plasma with the exception of at least one of the essential amino acids to be removed, wherein concurrent with said treatment of the blood, the patient is administered an effective amount of a composition which limits the release of muscular protein amino acids.
A method for the treatment of tumors in a patient comprising the steps of:
- 1) systemically removing an essential amino acid by extracorporeal treatment of the patient's blood by molecular exchange between the blood and a dialyzing fluid;
- 2) adding by infusion all of the essential low molecular substances found in blood plasma with the exception of the amino acid to be removed;
- 3) concurrent with said removal of the essential amino acid, administering to the patient an effective amount of a composition which limits the release of muscular protein amino acids.
Dependencies are inferred from the claim text.