Loading patent…
AssigneeTeijin Limited
InventorsTakashi Sugiyama, Takashi Kamimura, Kenichi Masuda, Masahiro Okada, Eiko Ohtsuka, Atsushi Imaizumi, Kunihito Watanabe, Tetsuya Suga, Yohichi Matsumoto, Akiko Takeuchi
Estimating the term…
The present invention provides an elastase inhibitory polypeptide comprising a C-terminal half of a human secretory leukocyte protease inhibitor (SLPI) and having an elastase inhibitory activity wherein inhibitory activity of a trypsin-like serine protease does not exceed 1/10 of elastase inhibitory activity, and polypeptides having the above-mentioned biological activity wherein one or more than one amino acid is added, one or more than one amino acid is deleted and/or one or more than one amino acid is replaced. The present invention also provides a process for the production of the above-mentioned protein or other protein via a corresponding fused protein.
An isolated and purified elastase inhibitory polypeptide consisting of an amino acid sequence represented by SEQ ID NO:2, wherein the polypeptide has a trypsin-inhibitory activity, the polypeptide trypsin-inhibitory activity being less than trypsin-inhibitory activity exhibited by SLPI.
An isolated and purified elastase inhibitory polypeptide consisting of an amino acid sequence represented by SEQ ID NO:1, wherein the polypeptide has a trypsin-inhibitory activity, the polypeptide trypsin-inhibitory activity being less than trypsin-inhibitory activity exhibited by SLPI.
An isolated and purified elastase inhibitory polypeptide consisting of an amino acid sequence represented by SEQ ID NO:3, wherein the polypeptide has a trypsin-inhibitory activity, the polypeptide trypsin-inhibitory activity being less than trypsin-inhibitory activity exhibited by SLPI.
Dependencies are inferred from the claim text.