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US 5,851,839 AGranted
Platelet aggregation inhibitors
AssigneeCOR Therapeutics, Inc.
InventorRobert M. Scarborough
Life of this patent
Estimating the term…
Abstract
Peptides useful in inhibiting platelet aggregation are disclosed. These peptides contain the binding sequence Har-G-D and are disulfide-bridged cyclic compounds.
Claims3
A method to detect the presence or absence of the peptide selected from the group consisting of:
- ______________________________________ PAI 80 Mpr-P-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:1) PAI 81 Mpr-G-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:2) PAI 82 Mpr-A-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:3) PAI 83 Mpr-Aib-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:4) PAI 84 Mpr-(N-Me-Arg)-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:5) PAI 85 Mpr-(N-Me-Ser)-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:6) PAI 86 Mpr-(D-Ala)-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:7) PAI 87 Mpr-(.beta.-Ala)-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:8) PAI 88 Mpr-(N-Me-Leu)-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:9) PAI 89 Mpr-(N-Me-Ala)-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:10) PAI 90 Mpr-Sar-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:11) PAI 91 Mpr-V-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:12) PAI 92 Mpr-S-Har-G-D-W-P-C-NH.sub.2 (SEQ ID No:13) PAI 93 Mpr-Har-G-D-W-P-A-C-NH.sub.2 (SEQ ID No:14) PAI 94 Mpr-Har-G-D-W-P-(N-Me-Ala)-C-NH.sub.2 (SEQ ID No:15) PAI 95 Mpr-Har-G-D-W-P-G-C-NH.sub.2 (SEQ ID No:16) PAI 96 Mpr-Har-G-D-W-P-(D-Ala)-C-NH.sub.2 (SEQ ID No:17) PAI 97 Mpr-Har-G-D-W-P-P-C-NH.sub.2 (SEQ ID No:18) PAI 98 Mpr-Har-G-D-W-P-(Sar)-C-NH.sub.2 (SEQ ID No:19) PAI 99 Mpr-Har-G-D-W-P-(Aib)-C-NH.sub.2 (SEQ ID No:20) PAI 100 Mpr-A-(Har)-G-D-W-P-Pen-NH.sub.2 (SEQ ID No:21) PAI 101 Mpr-A-K-G-D-W-P-Pen-NH.sub.2 (SEQ ID No:22), and PAI 102 Mpr-D-(Har)-G-D-W-P-Pen-NH.sub.2 (SEQ ID No:23) ______________________________________
- which method comprises contacting a sample suspected of containing said peptide with an antibody specifically immunoreactive with said peptide under conditions wherein a complex is formed in the presence of said peptide, and detecting the presence or absence of said complex.
Dependencies are inferred from the claim text.