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AssigneeThe General Hospital Corporation
InventorsBrian Seed, Babak Banapour, Charles Romeo, Waldemar Kolanus
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Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.
A human cell which expresses a proteinaceous membrane-bound chimeric receptor, said receptor comprising (a) an extracellular portion which includes a CD4 domain that specifically recognizes and binds HIV or an HIV-infected cell but which does not mediate HIV infection, (b) a transmembrane portion, and (c) an intracellular portion which signals said cell to destroy a receptor-bound HIV or HIV-infected cell.
DNA encoding a chimeric receptor comprising (a) an extracellular portion which includes a CD4 domain that specifically recognizes and binds HIV or an HIV-infected cell but which does not mediate HIV infection, (b) a transmembrane portion, and (c) an intracellular portion which signals said cell to destroy a receptor-bound HIV or HIV-infected cell.
Dependencies are inferred from the claim text.