Hepatitis B vaccine
AssigneeImperial College of Science, Technology and Medicine
InventorsHoward Christopher Thomas, William Frederick Carman
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Abstract
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAG antibodies.
Claims10
An expression vector comprising a DNA sequence encoding a variant hepatitis BS (vHBsAg) protein or fragment thereof said vHBsAg protein or fragment thereof comprising a modified "a" determinant of an S(HBs) protein in which the amino acid at position 145 at the HBs protein is arginine, said vHBsAg displaying an antigenicity different from that of wild-type S(vHBsAg) protein.
Dependencies are inferred from the claim text.