Inflammation-induced expression of a recombinant gene
AssigneeBoard of Regents, The University of Texas System
InventorRobert S. Munford
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Abstract
The present invention describes methods of controlling and regulating the inflammatory reaction generated in response to various toxins, immunogens, pathogens and autoimmune insults. The method employs a vector that includes an anti-cytokine protein or antibacterial protein gene under the control of a cytokine responsive promoter. In animal models, adenoviral vectors successfully delivered the vectors to hepatic cells and were subsequently shown to respond only to stimulation by induced cytokines.
Claims10
A nucleic acid segment comprising an anti-inflammatory protein gene positioned under the transcriptional control of a heterologous cytokine-responsive promoter.
A composition comprising a recombinant DNA that includes a heterologous cytokine inducible promoter gene and a DNA encoding an anti-inflammatory protein.
A kit comprising, in suitable container means, a pharmaceutically acceptable preparation of a replication defective adenovirus vector that includes an anti-inflammatory protein gene under the transcriptional control of complement factor 3 promoter or serum amyloid A3 promoter and means for administering said vector to a host cell.
Dependencies are inferred from the claim text.