MCH4 and MCH5, apoptotic proteases
AssigneeIdun Pharmaceuticals, Inc.
InventorsEmad S. Alnemri, Teresa Fernandes-Alnemri, Gerald Litwack, Robert Armstrong, Kevin Tomaselli
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Abstract
The invention provides an isolated gene encoding Mch4 or an isolated gene encoding Mch5 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch4 or Mch5 or functional fragment thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch4 or Mch5 nucleotide sequences. Isolated Mch4 or Mch5 polypeptides or functional fragments thereof are also provided.
Claims8
An isolated Mch4 polypeptide comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:2;
- amino acids 1 through 239 of SEQ ID NO:2;
- amino acids 102 through 346 of SEQ ID NO:2;
- and
- amino acids 102 through 239 of SEQ ID NO:2.
An isolated Mch5 polypeptide comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:4;
- and
- amino acids 1 through 284 of SEQ ID NO:4.
Dependencies are inferred from the claim text.