Human elastate IV
AssigneeHuman Genome Sciences, Inc.
InventorsJohn M. Green, Mark D. Adams
Life of this patent
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Abstract
Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Claims28
An isolated polypeptide comprising a polypeptide selected from the group consisting of:
- (a) a polypeptide consisting of amino acids 1 to 268 of SEQ ID NO:
- 2;
- (b) a polypeptide consisting of amino acids 2 to 268 of SEQ ID NO:
- 2;
- (c) a polypeptide consisting of amino acids 16 to 268 in SEQ ID NO:
- 2;
- (d) a polypeptide consisting of amino acids 30 to 268 in SEQ ID NO:
- 2;
- (e) a polypeptide having protease activity consisting of amino acids 30 to 268 of SEQ ID NO:
- 2, except for at least one conservative amino acid substitution;
- (f) a fragment of the polypeptide of (a) having protease activity;
- and
- (g) a fragment of the polypeptide of (a) which binds to an antibody specific for the polypeptide of (a).
An isolated polypeptide comprising a polypeptide selected from the group consisting of:
- (a) the full-length polypeptide encoded by the human cDNA contained in ATCC Deposit No. 75751;
- (b) the full-length polypeptide encoded by the human cDNA contained in ATCC Deposit No. 75751, excepting the N-terminal methionine;
- (c) the mature polypeptide encoded by the human cDNA contained in ATCC Deposit No. 75751;
- (d) a polypeptide having protease activity consisting of the amino acid sequence of the polypeptide of (c), except for at least one conservative amino acid substitution;
- (e) a fragment of the polypeptide of (a) having protease activity;
- and
- (f) a fragment of the polypeptide of (a) which binds an antibody specific for the polypeptide of (a).
Dependencies are inferred from the claim text.