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US 5,851,802 AGranted
Methods for recombinant microbial production of fusion proteins and BPI-derived peptides
AssigneeXoma Corporation
InventorMarc D. Better
Life of this patent
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Abstract
The present invention relates to methods and materials for the recombinant microbial production of fusion proteins and peptides derived from or based on Domain I (amino acids 17-45), Domain II (amino acids 65-99) and Domain III (amino acids 142-169) of bactericidal/permeability-increasing protein (BPI).
Claims15
A recombinant DNA vector construct suitable for introduction into a bacterial host comprising a coding sequence for a fusion protein having:
- (a) at least one cationic bactericidal/permeability-increasing (BPI) peptide encoding DNA sequence;
- (b) a carrier protein encoding DNA sequence;
- and (c) an amino acid cleavage site encoding DNA sequence located between the sequences (a) and (b), wherein the construct additionally encodes a bacterial secretory leader sequence at the amino-terminus of the fusion protein and wherein the encoded BPI peptide has anti-bacterial activity.
Dependencies are inferred from the claim text.