Tie ligand-3, methods of making and uses thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsDavid M. Valenzuela, Pamela F. Jones, George D. Yancopoulos
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Abstract
The present invention provides for an isolated nucleic acid molecule encoding TIE ligand-3. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3. The invention also provides an antibody which specifically binds TIE ligand-3. The invention further provides for an antagonist of TIE. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.
Claims15
An isolated nucleic acid molecule comprising a nucleotide sequence encoding TIE ligand-3, wherein the nucleotide sequence is selected from the group consisting of:
- (a) the nucleotide sequence encoding TIE ligand-3 as set forth in FIGS. 21A and 21B (SEQ. ID NO.7);
- and
- (b) a nucleotide sequence that, as a result of the degeneracy of the genetic code, differs from the nucleotide sequence of (a) and encodes a ligand that binds TIE-2 receptor.
Dependencies are inferred from the claim text.