US 5,851,787 A · Nucleic acid encoding amyloid precursor-like protein and uses thereof

Abstract

The present invention is directed to isolated amyloid precursor-like proteins (APLPs), nucleotide sequences coding for and regulating expression of these protein, antibodies directed against these proteins, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of these protein sequences. The invention is also directed to isolated genomic DNA, cDNA anti-sense RNA, and RNA containing the protein sequence. Antibodies can be used to detect an APLP in biological specimens, including, for example, fluid, serum or tissue samples. APLP1 and APLP2 are candidate genes for late onset familial Alzheimer's disease.

Claims9

Dependent claims

A recombinant nuleotide molecule encoding an amyloid precursor-like protein (APLP) polypeptide, comprising a nucleotide sequence encoding the amino acid sequence of SEQ ID NO:4, or a nucleotide sequence complementary thereto.

Dependencies are inferred from the claim text.

Facts

Application

08/007,999Filed 21 Jan 1993 · continuation in part

Priority

20 Apr 1992

Granted

22 Dec 1998

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07K 14/4711
Not used: alzheimer's disease; Amyloid plaque core protein
A61K 38/00
Medicinal preparations containing peptides
Y10S 530/81
Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof: carrier - bound or immobilized peptides or…
C07K
Peptides

Nucleic acid encoding amyloid precursor-like protein and uses thereof

Life of this patent

Nucleic acid encoding amyloid precursor-like protein and uses thereof

Life of this patent

Abstract

Claims9