Human phosphodiesterase type IVC, and its production and use
AssigneeCelltech Therapeutics Limited
InventorsRaymond John Owens, Martin John Perry, Simon Mark Lumb
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Abstract
Recombinant human phosphodiesterase type IVC is described, and DNA coding for it. Particular conformers of the enzyme are identified, including a R- and S-rolipram stereoselective conformer which is obtainable by expression of human phosphodiesterase type IVC DNA in mammalian or insect cells. The recombinant enzyme may be used in a screen to select a compound capable of modulating the action of the enzyme, or as an immunogen to generate an antibody.
Claims5
A recombinant phosphodiesterase comprising the amino acid sequence of FIGS. 2A to 2C herein (SEQ, ID No:
- 32), or a catalytically active fragment thereof.
A R- and S-rolipram stereoselective conformer of the phosphodiesterase according to claim 2.
Dependencies are inferred from the claim text.