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US 5,851,779 AGranted
Method for measuring carbamazepine in human serum
AssigneeDade Behring Inc.
InventorChengrong Wang
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Abstract
The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C=O, CH.sub.2 or SO.sub.2 ; Y is C=O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.
Claims2
A method for measuring carbamazepine in human serum comprising the steps of
- (1) incubating
- (a) a particle reagent covalently attached to at least one carfpe bamazepine hydrazide having the structural formula:
- ##STR12## (b) serum suspected of containing carbamazepine;
- and, (c) an agglutinating agent selected from the group consisting of an antibody to a carbamazepine compound, an antibody to an analog of carbamazepine of a carbamazepine compound, an antibody to an antigen analog of a carbamazepine compound;
- and
- (2) photometrically measuring increased particle size resulting from agglutination.
3 more elements
Dependencies are inferred from the claim text.