Use of a salt of an alkaline-earth metal as TNF-A or substance P inhibitor in a topical composition and composition obtained

A method of treating at least one of sensitive skin and skin reddening of neurogenic origin in a mammal comprising administering a pharmaceutical, cosmetic, dermatological or veterinary composition which comprises an effective amount of at least one alkaline-earth metal or pharmaceutically, cosmetically, or dermatologically acceptable salt thereof wherein said alkaline-earth metal possesses TNF-alpha inhibitory activity.

A method of treating a pathological and/or physiological disorder associated with the release of TNF-alpha in a mammal comprising administering a pharmaceutical, cosmetic, dermatological or veterinary composition which comprises an effective amount of at least one alkaline-earth metal or a pharmaceutically acceptable salt thereof, the alkaline-earth metal moiety having TNF-alpha inhibitory activity.

A method of treating a disorder selected from the group consisting of rosacea, comprising administering a cosmetic, pharmaceutical, dermatological or veterinary composition comprising an effective amount of at least one alkaline-earth metal or cosmetically, pharmaceutically, or dermatologically acceptable salt thereof, the alkaline-earth metal moiety having TNF-alpha inhibitory activity.

A method of treating a disorder associated with the release of substance P comprising administering to a mammal in need of such treatment an effective amount of at least one strontium salt contained in a cosmetically, pharmaceutically, dermatologically or veterinary acceptable carrier.

A method of treating a condition selected from the group consisting of skin conditions, bronchopulmonary conditions, pain, gastrointestinal conditions and central nervous system disorders comprising administering to a mammal in need of such treatment an effective amount of at least one strontium salt contained in a cosmetically, dermatologically, pharmaceutically or veterinary acceptable carrier.

A method of treating a condition selected from the group consisting of atopic dermatitis, eczema, psoriasis and acne comprising administering to a mammal in need of such treatment an effective amount of at least one strontium salt.

A method for inhibiting at least one of the attachment, the synthesis, or the release of TNF-alpha in the skin, comprising applying to at least one of the skin, the scalp and the mucous membranes a cosmetic composition containing an effective amount at least one alkaline-earth metal salt which alkaline-earth metal inhibits TNF-alpha activity contained in a cosmetically acceptable medium.

A method for the cosmetic treatment of at least one of sensitive skin or skin reddening of neurogenic origin, comprising applying to at least one of the skin, the scalp or the mucous membranes, which are sensitive or are affected by rosacea or are both sensitive and affected by rosacea, a composition containing an effective amount of at least one alkaline-earth metal salt which alkaline-earth metal inhibits TNF-alpha activity in a cosmetically acceptable medium.

A method for the cosmetic treatment of the pruriginous symptoms of disorders or diseases of at least one of the skin or the mucous membranes, comprising applying to at least one of the skin, the scalp, and the mucous membranes a composition containing an effective amount of at least one salt of at least one alkaline-earth metal which alkaline-earth metal inhibits TNF-alpha activity contained in a cosmetically acceptable medium.

A method for the cosmetic treatment of a physiological disorder associated with the release of substance P, comprising applying to at least one of the skin, the scalp and the mucous membranes a composition containing an effective amount of at least one strontium salt contained in a cosmetically acceptable medium.