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US 5,851,555 AGranted
Controlled release dosage forms containing water soluble drugs
AssigneeFuisz Technologies Ltd.
InventorsPradeepkumar P. Sanghvi, Tushar K. Misra, David V. Prior
Life of this patent
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Abstract
Controlled release dosage units containing water soluble active agents can be made using an active agent, an optional inert carrier, a cellulosic polymer and a lipophilic ingredient.
Claims17
Compositions suitable for making controlled release dosage forms consisting essentially of
- about 5 to about 40 parts of a water soluble active agent;
- about 0 to about 15 parts of an inert carrier;
- about 5 to about 45 parts cellulosic polymer;
- and
- about 0.1 to about 45 parts lipophilic ingredient,
- wherein the lipophilic ingredient is at least one selected from the group consisting of:
- a fatty acid ester, a wax, a fat or cetyl alcohol.
4 more elements
A method of making a controlled release dosage unit comprising the steps of:
- (1) mixing an active agent or active agent/carrier pre-blend with cellulosic polymer, lipophilic ingredient, fillers, and lubricant;
- (2) melting, cooling, and milling the mixture of step (1) to yield a solid dispersion in granulate form;
- (3) mixing the granulate of step (2) with additional amounts of cellulosic polymer, fillers, and lubricant;
- and
- (4) compressing the mixture of step (3) into a dosage unit, wherein the lipophilic ingredient is at least one selected from the group consisting of:
- a fatty acid ester, a wax, a fat or cetyl alcohol.
3 more elements
A controlled release dosage unit produced from a composition comprising:
- about 5 to about 40 parts of a water soluble active agent;
- about 0 to about 15 parts of an inert carrier;
- about 5 to about 45 parts cellulosic polymer;
- and
- about 0.1 to about 45 parts lipophilic ingredient,
- wherein the lipophilic ingredient is at least one selected from the group consisting of:
- a fatty acid ester, a wax, a fat or cetyl alcohol.
4 more elements
Dependencies are inferred from the claim text.