Delivery of controlled-release system(s)
AssigneeFuisz Technologies Ltd.
InventorsGarry L. Myers, Gerald E. Battist, Richard C. Fuisz
Life of this patent
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Abstract
The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.
Claims15
A composition for preparing uncured comestible units having controlled release properties comprising microparticulates containing a mixture of:
- a controlled-release system containing an active ingredient and
- amorphous saccharide-based shearform masses.
A composition for making a quick dissolve comestible unit having controlled release properties, said composition being microparticulate and being made by mixing a controlled release system and shearform masses using the following steps:
- i) initiating crystallization in the outer portions of amorphous saccharide-based shearform masses,
- ii) before or after step i), combining a controlled release system with said masses to form micro-particulates,
- iii) compacting said micro-particulates to form a unit dosage, and
- iv) converting the remaining portions of said masses to a substantially completely crystalline structure which is continuously bound and stabilized while incorporating said controlled release system in said saccharide-based crystalline structure.
An uncured composition for preparing comestible units comprising compactible microparticulates consisting essentially of:
- (a) amorphous masses of sacchride-based shearform matrix particles,
- (b) a controlled release delivery system, and
- (c) at least one active ingredient, wherein the microparticulates can withstand compaction force without experiencing an increase in density.
Dependencies are inferred from the claim text.