US 5,851,546 A · Polymer composition for controlled release of active ingredients in response to pH, and a process of preparing the same

Abstract

The present invention provides a polymer for the controlled release of a pendent chain linked active ingredient, and a process for the preparation of such a polymer for the controlled release of an active ingredient in response to pH. The process involves selecting a vinyl monomer to which the active ingredient molecule is covalently linked through a pendent group, and selecting monomers bearing catalytic groups. The active ingredient-bearing monomer and the catalytic group-containing monomer are brought in juxtaposition either by complexation or molecular imprinting, and then polymerized with a hydrophilic monomer and crosslinker under an inert atmosphere with a suitable polymerization initiator.

Claims23

Dependent claims

A polymer for the controlled release of an active ingredient, the polymer having the general formula A.sub.x B.sub.y C.sub.z S.sub.q wherein A is an imidazole group-bearing vinyl monomer, B is a hydroxyl group-bearing vinyl monomer, C is a carboxyl group-bearing vinyl monomer, and S is a vinyl monomer covalently bonded to an active ingredient through an amide or an ester;

and
x+y+z+q=1;
and x, y, z, q can vary such that 0<x<1, and 0<q<1, and y and z can vary between 0 to 1.

Dependencies are inferred from the claim text.

Polymer composition for controlled release of active ingredients in response to pH, and a process of preparing the same

Life of this patent

Polymer composition for controlled release of active ingredients in response to pH, and a process of preparing the same

Life of this patent

Abstract

Claims23