Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
AssigneeAdvanced Polymer Systems, Inc.
InventorsMichael Froix, Masha Pukshansky, Sergio Nacht
Life of this patent
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Abstract
Retinoids for topical skin application are formulated as impregnants in porous microspheres. Thus formulated, the retinoids display a surprisingly high level of stability and low degree of skin irritation.
Claims16
A stable pharmaceutical composition for topical administration of retinol consisting of an oil-in-water emulsion comprising, suspended in the emulsion, solid water-insoluble microscopic particles containing a substantially continuous network of pores open to the exterior of the particles and a retinoid composition comprising retinol residing only in the pores, the composition causing lower irritancy when applied than a composition containing the same concentration of retinol in a non-(microscopic particle) formulation.
A stable pharmaceutical composition for topical administration of retinol consisting of an oil-in-water emulsion comprising, suspended in the emulsion, solid water-insoluble microscopic particles containing a substantially continuous network of pores open to the exterior of the particles and a retinoid composition comprising retinol residing only in the pores, the concentration of the retinoid composition relative to the pharmaceutical composition being between about 0.001% and about 20.0% by weight, the composition causing lower irritancy when applied than a composition containing the same concentration of retinol in a non-(microscopic particle) formulation.
A stable pharmaceutical composition for topical administration of retinol consisting of an oil-in-water emulsion comprising, suspended in the emulsion, solid water-insoluble microscopic particles containing a substantially continuous network of pores open to the exterior of the particles and a retinoid composition comprising from about 5% to about 60% by weight of retinol, from about 10% to about 75% by weight of an antioxidant, from about 0.01% to about 1% by weight of a chelating agent, and a surfactant, residing only in the pores, the concentration of the retinoid composition relative to the pharmaceutical composition being between about 0.01% and about 5.0% by weight, the composition causing lower irritancy when applied than a composition containing the same concentration of retinol in a non-(microscopic particle) formulation.
Dependencies are inferred from the claim text.