Methods for prevention and/or treatment of neutropenia
AssigneeDynaGen, Inc.
InventorsFazal Raheman, Nicolae Istrate, Gita Muni, Edgard Brauner
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Abstract
The present invention is directed to a method of treating individuals exhibiting neutropenia or at risk of neutropenia. The method comprises the step of administering to an individual exhibiting neutropenia or at risk of neutropenia, an effective amount of a colony modulating factor derived from bacteria. The colony factor modulator exhibits an immunomodulating effect in humans and promotes a stabilization or increase in neutrophil count.
Claims18
A method of treating neutropenia in a human subject comprising the step of administering to a human subject exhibiting neutropenia or at risk of developing neutropenia a colony modulating factor derived from pseudomonas in an amount effective for inhibiting a decrease in the number of neutrophils in the subject, wherein the colony modulating factor is a pseudomonas solvent extract which is prepared by the steps of incubating a pseudomonas culture with a ketone to produce a first precipitate, wherein the ketone is a lower C.sub.2 -C.sub.6 ;
- mixing the first precipitate with an alcohol to produce an alcohol extract, wherein the alcohol is a lower C.sub.1 -C.sub.6 ;
- collecting the alcohol extract;
- and
- precipitating an active material from the alcohol extract with a lower C.sub.1 -C.sub.6 ketone to produce the pseudomonas solvent extract.
Dependencies are inferred from the claim text.