Back to results
US 5,851,529 AGranted
Recombinant retroviruses
OwnerHarry E. Guber, Douglas J. Jolly +2inventors
InventorsHarry E. Guber, Douglas J. Jolly, James G. Respess, Paul K. Laikind
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerHarry E. Guber, Douglas J. Jolly +2inventors
InventorsHarry E. Guber, Douglas J. Jolly, James G. Respess, Paul K. Laikind
Estimating the term…
Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
A method of stimulating a cell-mediated immune response to a viral or cancer antigen in a human, comprising infecting susceptible target cells with a replication defective recombinant retrovirus construct directing the expression of said viral or cancer antigen or mutated form thereof in said infected target cells, wherein said viral antigen is from a virus that is pathogenic to humans, and wherein said antigen or mutated form thereof elicits a cell-mediated immune response directed to said viral or cancer antigen or mutated form thereof in said human.
A method of stimulating a cell-mediated immune response to a viral or cancer antigen in a human, comprising:
Dependencies are inferred from the claim text.