Enhancing keratinocyte migration
AssigneeTrustees of Tufts College
InventorIra M. Herman
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Abstract
This invention relates to the use of a particular form of collagenase substantially free of other proteinases to increase the motility of karatinocytes.
Claims8
A method of enhancing the migration and proliferation of keratinocytes in human wound healing which comprises contacting same with an effective amount of purified Clostridiopeptidase A collagenase substantially free from other proteinases.
A method of treating an open wound in human skin which comprises contacting exposed sub-cellular matrix with purified Clostridiopeptidase A collagenase substantially free from other proteinases in a concentration effective to enhance the rate of migration of keratinocytes towards the wound edges.
A method of enhancing the migration and proliferation of keratinocytes in mammalian wound healing which comprises contacting same with an effective amount of purified Clostridiopeptidase A collagenase substantially free from other proteinases.
A method of treating an open wound in mammalian skin which comprises contacting exposed sub-cellular matrix with purified Clostridiopeptidase A collagenase substantially free from other proteinases in a concentration effective to enhance the rate of migration of keratinocytes at the wound edges.
Dependencies are inferred from the claim text.