Viral vectors and their use for treating hyperproliferative disorders, in particular restenosis
AssigneeCase Western Reserve University
InventorsDidier Branellec, Kenneth Walsh, Jeffrey M. Isner, Patrice Denefle
Life of this patent
Estimating the term…
Abstract
The present invention relates to replication defective recombinant viruses which contain at least one inserted gene encoding all or part of the protein GAX or of a variant of this protein, and to their therapeutic use, in particular for treating post-angioplastic restenosis.
Claims36
A method for inhibiting proliferation of mammalian vascular smooth muscle cells, said method comprising locally administering to said cells a replication defective recombinant adenovirus comprising a gene encoding a mammalian GAX protein, wherein said gene is expressed and proliferation of said cells is inhibited.
A method of inhibiting restenosis in a patient, said method comprising administering to vascular smooth muscle cells at a predetermined site in said patient a replication defective recombinant adenovirus comprising a gene encoding a mammalian GAX protein wherein said gene is expressed in vascular smooth muscle cells of said patient and inhibits proliferation of said cells.
Dependencies are inferred from the claim text.