Live vaccines
AssigneesGlaxo Wellcome Inc., The Royal Society, The Lister Institute of Preventive Medicine, University Court of the University of Dundee
InventorsGordan Dougan, Steven Neville Chatfield, Christopher Francis Higgins, Charles James Dorman
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Abstract
The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine. In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.
Claims13
A method of inducing immunity in a host to a pathogenic bacterium that infects by the oral route, which method comprises orally administering to the host a bacterium which is attenuated by a non-reverting mutation in the ompR gene and which expresses an antigen of the pathogenic bacterium.
Dependencies are inferred from the claim text.