US 5,851,511 AGranted

Polyiodo compounds, their preparation and their use in X-ray radiology

AssigneeGuerbet

InventorsGael Le Lem, Dominique Meyer

Life of this patent

Estimating the term…

Loading patent…

Abstract

The invention relates to compounds of formula: ##STR1## in which T.sub.i, V.sub.i, T'.sub.i and V'.sub.i with i=0, 1 or 2, represent O, COND or NDCO, D being H, alkyl or (poly)hydroxyalkyl; Q.sub.i and Q'.sub.i with i=0, 1 or 2, represent alkylene or (poly)hydroxyalkylene; Ar.sub.i and Ar'.sub.i with i=1 or 2, represent ##STR2## in which R, R.sub.3, R.sub.4 are COOH and R', R'.sub.3, R'.sub.4 are CONR'.sub.1 R'.sub.2 or N(R'.sub.1)COR'.sub.2, R' and R'.sub.2 being H, alkyl or (poly)hydroxyalkyl such that R'.sub.1 and R'.sub.2 together comprise at least 4 hydroxyl groups, or R.sub.i and R'.sub.i with i=nothing, 3 or 4 represent CONR'.sub.1 R'.sub.2 or N(R'.sub.1)COR'.sub.2, R'.sub.1 and R'.sub.2 together comprising at least 6 hydroxyl groups, or else R.sub.i and R'.sub.i with i=3 or 4 represent T--Q--V--Ar, T, Q and V being as defined above for T.sub.i, Q.sub.i and V.sub.i and Ar having formula II, and A is a biocompatible radical of molecular weight less than 1200 having two valences such as to give with T.sub.o and T'.sub.o an amide or ether group.

Claims24

Dependent claims

Compound of formula ##STR36## in which D is selected from the group consisting of H, C.sub.1 to C.sub.6 alkyl and C.sub.1 to C.sub.6 hydroxyalkyl or polyhydroxyalkyl,

Ar.sub.1 represents a group of formula (II):
##STR37## wherein R is COOH and R' is selected from the group consisting of CONR'.sub.1 R'.sub.2 and N(R'.sub.1)COR'.sub.2, R'.sub.1 and R'.sub.2 being selected from the group consisting of H, C.sub.1 to C.sub.4 alkyl and C.sub.1 to C.sub.8 hydroxyalkyl or polyhydroxyalkyl such that NR'.sub.1 R'.sub.2 comprises more than 4 hydroxyls, or R and R' are identical and represent --CONR'.sub.1 R'.sub.2, R'.sub.1 and R'.sub.2 being selected from the group consisting of H, C.sub.1 to C.sub.4 alkyl and C.sub.1 to C.sub.8 hydroxyalkyl or polyhydroxyalkyl such that R'.sub.1 and R'.sub.2 together comprise more than 6 hydroxyls,
or Ar.sub.1 represents a group of formula (III):
##STR38## wherein R'.sub.1 and R'.sub.2 are selected from the group consisting of H, C.sub.1 to C.sub.4 alkyl and C.sub.1 to C.sub.8 hydroxyalkyl or polyhydroxyalkyl such that R'.sub.1 and R'.sub.2 together comprise more than 6 hydroxyls,
Q.sub.0, Q.sub.1 and Q.sub.3, which are identical or different, are selected from the group consisting of C.sub.1 to C.sub.6 alkylene and C.sub.1 to C.sub.6 hydroxyalkylene or polyhydroxyalkylene,
A is a biocompatible radical from an aliphatic or aromatic molecule of molecular weight less than 1200 having two free valences for linking to COND, as well as their pharmaceutically acceptable salts with bases.

3 more elements

Dependencies are inferred from the claim text.