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US 5,851,230 AGranted
Vascular graft with a heparin-containing collagen sealant
AssigneeMeadox Medicals, Inc.
InventorsKevin Weadock, David J. Lentz, Jack Tant
Life of this patent
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Abstract
A heparin-collagen dispersion is provided for impregnating a vascular prosthesis with heparin and collagen. The dispersion is prepared at an alkaline pH to allow the addition of heparin without causing the agglutination of collagen from the dispersion. The impregnation of collagen and heparin within the prosthesis effectively prevents blood loss and thrombus formation after implantation of the prosthesis.
Claims10
A synthetic vascular prosthesis comprising:
- a collagen-heparin dispersion at alkaline pH within a range from about 9 to about 11;
- said dispersion being applied to said prosthesis to effectuate sealing and impart enhanced anti-thrombogenic property thereto;
- wherein the collagen applied to said prothesis is crosslinked.
A synthetic vascular prosthesis comprising:
- a flexible, porous, tubular substrate having a intraluminal and an extraluminal surface, wherein a least said intraluminal surface is treated with an alkaline collagen-heparin sealant prepared with an alkaline dispersion of collagen and heparin wherein said dispersion is maintained within a pH range of between about 9 to about 11.
Dependencies are inferred from the claim text.